NPJ | Cardiovasc Health, part of the Nature Portfolio

This landmark study published in npj Cardiovascular Health showed that childhood polygenic risk score (PRS)-guided prevention for coronary artery disease (CAD) could enable earlier targeted intervention, reduce future cardiovascular events, and generate major long-term health and economic benefits. The study projected that early identification of high-risk children could prevent 72 CAD events per 10,000 children and achieve a return on investment (ROI) exceeding 3600%, supporting a shift toward genome-first, early-life preventive cardiology.