The New England Journal of Medicine | The Inherited Basis of Coronary Artery Disease

The Inherited Basis of Coronary Artery Disease

This NEJM 2026 review shows that CAD polygenic risk scores (PRS) identify a high-risk group, often missed by traditional calculators and meaningfully improve risk prediction and provide absolute benefit is greatest in high-PRS individuals.





JAMA | Risk-Based vs Annual Breast Cancer Screening

Risk-Based vs Annual Breast Cancer Screening The WISDOM Randomized Clinical Trial

This landmark JAMA 2025 trial showed that PRS-powered risk-based breast cancer screening was non-inferior to annual screening and was associated with an approximately one-third lower rate of advanced cancer.
This landmark JAMA 2025 WISDOM trial showed that PRS-powered risk-based breast cancer screening was non-inferior to annual screening and was associated with an approximately one-third lower rate of advanced (stage ≥IIB) cancers (30.0 vs 48.0 per 100,000 person-years), with nearly doubled uptake of preventive therapy among the highest-risk women, establishing PRS-guided screening as a scalable and clinically sound strategy.

The New England Journal of Medicine | Assessment of a Polygenic Risk Score in Screening for Prostate Cancer

This landmark NEJM 2025 study showed that PRS-guided screening uncovers many high-risk prostate cancers missed by standard PSA pathways.

This landmark NEJM 2025 study showed that PRS-guided screening of men in the top genetic risk decile substantially improves detection of clinically significant prostate cancer, uncovering many high-risk cancers missed by standard PSA pathways, and establishes PRS-based risk stratification as a scalable, clinically impactful screening strategy.